NEW YORK — The visiting Denver Broncos returned two interceptions for touchdowns in the first quarter and coasted to a 45-10 victory over the Arizona Cardinals on Thursday night in Glendale, Ariz.

Emmanuel Sanders caught six passes for 102 yards and a touchdown and threw for another, as Denver (3-4) snapped a four-game losing streak. Broncos quarterback Case Keenum went 14 of 21 for 161 yards, a touchdown and an interception.

Rookie Josh Rosen finished 21 of 39 for 194 yards, a touchdown and three picks as Arizona (1-5) failed on its first seven third-down conversion attempts after going 0-for-10 last week. Rosen limped off in the final minutes after getting sacked for the sixth time.

Entering the game ranked last in total offense and 31st in scoring, the Cardinals got off to a disastrous start. On the second play from scrimmage, Rosen's pass was tipped by Derek Wolfe and intercepted by Todd Davis, who returned it 20 yards for a 7-0 lead.

After an Arizona three-and-out, the Broncos' offense marched 77 yards in six plays on its first possession for a 14-0 lead. Sanders capped it with a 28-yard reverse pass to rookie wideout Courtland Sutton, who made a diving grab.

A 43-yard Phil Dawson field goal cut it to 14-3 before Denver's defense scored again. Rosen threw a slant to J.J. Nelson, who stopped his route as Chris Harris Jr. intercepted it and returned it 53 yards for a 21-3 advantage with 2:13 left in the first.

Keenum opened the Broncos' next possession with a 64-yard bomb to Sanders two plays into the second quarter, pushing the lead to 28-3. Rookie running back Royce Freeman's 1-yard plunge 21 seconds before halftime made it 35-3. The Broncos outgained the Cardinals 237 to 82 before the break.

Rosen hit Larry Fitzgerald from 4 yards out midway through the third to cut into the lead. Phillip Lindsay's 28-yard scamper and Brandon McManus' 41-yard field goal capped the scoring. Both were set up by strip-sacks from Von Miller, who added four QB hits.

Cards QB Rosen on

toe injury: 'I'm fine'

Cardinals rookie quarterback Josh Rosen, who injured a toe on his left foot late in Arizona's blowout loss to the Denver Broncos on Thursday, downplayed the ailment postgame.

"I'm fine," he said after the Cardinals' 45-10 defeat in Glendale, Ariz. Referring to leaving the game limping, he said, "I was just being soft."

Arizona coach Steve Wilks added, "From early talking to him, he thinks he is fine, but I am not going to sit here and say that. That may be the case. We have to make sure we get the evaluation from the trainer."

Rosen was injured while getting sacked on a fourth-and-16 with two minutes left and the Cardinals down by 35 points. Wilks admitted his probably should have removed Rosen earlier, but the 21-year-old quarterback disagreed.

"Football is a violent sport," Rosen said. "I'd definitely rather stay in there and see as many defenses as I possibly as I can as early in my career as I can. If (Wilks) tried to pull me out, we would have definitely had to have a conversation about that one."

Rosen, the 10th overall pick in this year's draft out of UCLA, completed 21 of 39 passes for 194 yards and one touchdown. — Reuters